Tesofensine is a centrally-acting serotonin–noradrenaline–dopamine reuptake inhibitor (SNDRI) developed primarily for the treatment of obesity. It was originally investigated for Parkinson’s disease and Alzheimer’s disease, but researchers noticed it caused significant weight loss in clinical trial participants. This led to its development as an anti-obesity drug.
How Tesofensine Works:
Tesofensine increases levels of three key neurotransmitters in the brain:
- Dopamine
- Serotonin
- Noradrenaline (norepinephrine)
These chemicals affect appetite, mood, and energy expenditure, leading to:
- Reduced appetite
- Increased satiety
- Enhanced energy usage
Potential Benefits of Tesofensine:
- Weight Loss
- In clinical trials, tesofensine showed significant weight reduction:
- Up to 10% body weight loss over 24 weeks in obese individuals.
- Greater efficacy than many current weight-loss medications.
- In clinical trials, tesofensine showed significant weight reduction:
- Improved Metabolic Markers
- Potential improvements in:
- Cholesterol
- Blood sugar
- Insulin sensitivity
- Potential improvements in:
- Appetite Suppression
- Strong appetite-reducing effects, which can help with calorie control.
- Once-Daily Oral Dose
- Easy administration as a daily pill.