Low Dose Naltrexone (LDN) for Weight Loss – What You Should Know
Low Dose Naltrexone (LDN) is a medication that has gained attention in recent years for its potential off-label uses, including weight loss. Here’s an overview of how it may work, the evidence behind it, and important considerations:
What is Low Dose Naltrexone (LDN)?
- Naltrexone is an opioid receptor antagonist typically used at 50 mg/day to treat alcohol and opioid dependence.
- LDN refers to much smaller doses, typically 0.5–4.5 mg/day, used for other purposes, including chronic pain, autoimmune disorders, and, more recently, weight loss.
How Might LDN Help With Weight Loss?
- Appetite Regulation:
- LDN may modulate the hypothalamic-pituitary-adrenal (HPA) axis and suppress appetite.
- It may increase endorphin levels, improving mood and reducing emotional eating.
- Insulin Sensitivity & Metabolism:
- Some theories suggest it may improve insulin resistance, which could help with metabolic syndrome and fat loss.
- May work synergistically with other medications like bupropion (as in Contrave).
- Anti-Inflammatory Effects:
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- LDN reduces chronic low-grade inflammation, which is increasingly associated with obesity and metabolic dysfunction.
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- Improved Sleep and Mood:
- Better sleep and mood stability may indirectly support weight management.
- Research is limited and mostly anecdotal. LDN is not FDA-approved for weight loss.
- Sometimes couple with Welbutrin for extra support.